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What happened to the Indian tribes after the mission was built?

The Indian Tribes in California suffered a severe decline population after the arrival of the Europeans. Diseases that they were not protected against (Smallpox, for example) had a devastating effect. Some Indians covered to Christianity, others escaped to the interior.

Ultimately the remnants of some of the tribes were put on reservations. The Pala Sub-mission (bout 25 miles east of San Luis Rey) is on an Indian Reservation and the church there is still serving the native american population.