The California Missions Resource Center Store will closed until June 30. You are free to place orders but they will not be shipped until the store reopens.
What happened to the Indian tribes after the mission was built?
The Indian Tribes in California suffered a severe decline population after the arrival of the Europeans. Diseases that they were not protected against (Smallpox, for example) had a devastating effect. Some Indians covered to Christianity, others escaped to the interior.
Ultimately the remnants of some of the tribes were put on reservations. The Pala Sub-mission (bout 25 miles east of San Luis Rey) is on an Indian Reservation and the church there is still serving the native american population.