1827 - 1827

1827-1828 – A major measles epidemic erupts in Alta California and 951 adults and 751 children die over these two years. This represents over 10% of the mission population.

1828-1829 – Estanislao, a San José mission neophyte, leads a large-scale Indian uprising that requires several military expeditions to quell from 1828 to 1829.